SMPD2 and breast cancer: In MDA-MB231 breast cancer cells, resveratrol exposure led to both de novo ceramide biosynthesis associated with the activation of serine palmitoyltransferase, the key enzyme of de novo ceramide biosynthetic pathway, and a sphingomyelin hydrolysis linked to the activation of neutral sphingomyelinase, the main enzyme involved in the sphingomyelin/ceramide pathway49.