CDK4 and cancer: In order to determine whether the effect of resveratrol on metabolism is specific to cancer cells or would also affect normal cells, we used a human normal colonic epithelial cell line HCEC 1CT derived from a healthy patient that was been immortalized with cyclin-dependent kinase 4 (cdk4) and the catalytic component of the human ribonucleoprotein enzyme telomerase (hTERT).