TP53 and neoplasm: The metabolic effect resveratrol has been compared between normal HCEC 1CT and the isogenic derivative cell line HCEC 1CT RPA, a more tumor progressed cell line that is characterized by 90% knockdown of APC and TP53, and the ectopic expression of KRAS, mimicking the three major alterations found in colorectal cancers23–26.