Despite the lack of knowledge regarding the specific role of pSer-324–positive tau species in disease pathogenesis, the fact that pSer-324 and pSer-262/356 are detected in both animal models and patients with AD, combined with what has been learned from previous studies, provides strong rationale for the development of a therapeutic strategy aimed at preventing hyperphosphorylation of all of tau's KXGS motifs. The gene discussed is MAPT; the disease is Alzheimer disease.