Alzheimer’s disease (AD) is the most common form of tauopathy where tau aggregates to form somatodendritic neurofibrillary tangles (NFTs), parenchymal neuropil threads and dystrophic neurites that are intertwined with extracellular deposits of amyloid-β peptides [15, 29, 31, 46]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.