To address the controversy regarding the possible role of sRAGE in CVD, we have investigated the association between circulating sRAGE and early markers of vascular disease including arterial stiffness [pulse wave velocity (PWV)], central aortic blood pressure, arterial wave reflections [central augmentation pressure (AP), augmentation index (AIx)] and intima-media thickness (IMT), as well as biomarkers of subclinical myocardial injury and stress [cardiac troponin T (cTnT) and N-terminal pro B-type natriuretic peptide (NT-proBNP)], separately in those with and without diabetes. This evidence concerns the gene NPPB and diabetes mellitus.