Mild hypothermia previously showed inhibitory effects on the IL-6 pathway in human and mouse stroke, in HUVEC endothelial cell line culture, in rat pancreatitis and cardiac arrest models [20,47–49], which were at least partly mediated through NF-kB inhibition [20,47], and WBC also showed anti-IL-6 effects in RA patients without corticosteroids [50]. Here, NFKB1 is linked to rheumatoid arthritis.