Following the observation that CD11c+ cells deficient in Map3k8 mediate resistance to H. polygyrus infection (Fig 4) and the recent observation that elevated Ccl24 from CD11c+ MHC-II+ cells in Map3k8–/–mice contributed to enhanced HDM-driven airway allergy [17], we hypothesized that elevated Ccl24 in Map3k8–/–mice could be responsible for accelerated resistance to H. polygyrus. We therefore determined the expression of Ccl24 in CD11c+ cells from the lamina propria of the duodenum and jejenum of H. polygyrus infected WT and Map3k8–/–mice (Fig 5A). The gene discussed is ITGAX; the disease is allergic respiratory disease.