CD4 and tuberculosis: The cumulative data indicated that the initiation of efficient TB treatment did not significantly influence 1) the Mtb-specific CD4 T-cell functional profiles (P>0.05) (Fig 6E), 2) the nature and the amount of Th2 cytokines produced i. e. IL-4 and/or IL-5 and/or IL-13 (P>0.05) (S6A Fig) and 3) the transcription factor profile of TB and Mtb/helminth infected patients from TZ (P>0.05) (S6B Fig).