CNR2 and Hepatic fibrosis: Compared with the 129 patients with lower HAI scores, the 37 patients with moderate or severe necroinflammation more frequently had the CB2-RR variant (65.6% vs. 47.3%, p = 0.01) and showed higher AST (112.0 vs. 54.0, p = 0.000001), ALT (137.0 vs. 72.0, p = 0.0004), and ALP (205.0 vs. 179.0, p = 0.008) serum levels and higher liver fibrosis scores (3.6 ± 1.5 vs 1.9 ± 1.4, p< 0.0001, and steatosis scores (2.0 ± 1.3 vs 1.6 ± 1.3, p = 0.03) (Table 2).