In our previous study performed on 253 anti-HIV negative subjects with HCV chronic infection the CB2-63 QQ variant and an older age were found to be independently associated with an asymptomatic, inactive condition characterized by persistently normal alanine-aminotransferase (PNALT) values at a two-monthly determination for 18 months or more [50], whereas in a subsequent investigation on 169 anti-HIV-negative patients with HCV-related chronic hepatitis, the CB2-63 QQ variant was associated with more severe liver necroinflammation [53]. The gene discussed is GPT; the disease is chronic hepatitis.