If the BMIs of the controls and patients had not been matched, it may have influenced obestatin and ghrelin secretion independent of the heart disease, as an increase in ghrelin level has been correlated with a decrease in body weight.41 A weakly negative correlation was also found between the serum acylated ghrelin and BMI in the IHD subjects, but there was no correlation in the controls. The gene discussed is GHRL; the disease is heart disorder.