Mutations in the MEFV (MEditerranean FeVer) gene, which encodes for a protein called pyrin, is necessary for a diagnosis of FMF.3 Mutated pyrin is associated with uncontrolled inflammation and it increases circulatory levels of acute-phase reactants and cytokines secreted by the neutrophils.4 It has been shown that underlying subclinical inflammation is present during attack-free periods in patients with FMF.3 Here, MEFV is linked to familial Mediterranean fever.