Interestingly, when these 13 genes were inspected for possible association with cancer using the COSMIC Cancer Gene Census, only REL and ARID1B were found to be previously implicated in cancer.21 TCGA analysis suggests REL, ARID1B and associated genes can drive lung carcinogenesis through DNA damage and chromatin remodeling induced genomic instability (Figure 4). Here, ARID1B is linked to cancer.