MALT1 and melanoma: Next, we examined melanoma cell growth response to MI-2, a pharmacological agent that inhibits MALT1 function.40 By MTT analysis, we found that, while all cell lines responded to MI-2, A2058, A375 and CRL7426 appeared more sensitive than WM35, CRL7425 and SKmel28 (Supplementary Figures S2a and b).