By immunoblotting, we found that MALT1 was expressed at elevated levels in the majority of metastatic melanoma cell lines, including B16, A2058, A375, DM598, DM733, DM788 and CRL7426, as well as CRL7425 (a primary tumor cell line isogenic with CRL7426) and the vertical growth WM115 cells compared with normal melanocytes and the radial growth WM35 cells (Figure 1a). The gene discussed is MALT1; the disease is melanoma.