In addition, these tumors exhibited intense immunostaining of E-cadherin (Figure 2f), an epithelial cell marker expressed in normal melanocytes,46 and evidently reduced expression of N-cadherin (Figure 2g), a mesenchymal cell marker and promotor of melanoma growth and survival.47, 48, 49 Together, these results indicate that MALT1 plays a major role in melanoma growth and malignant progression. The gene discussed is MALT1; the disease is melanoma.