Our previous study identified that MeCP2 shRNA suppressed GC tumor growth.33 The present study goes a step forward, demonstrating that miR-638 suppresses MeCP2 expression by binding directly to the 3′-UTR of MeCP2, and there is an inverse correlation between miR-638 and MeCP2 expression in GC tissues. This evidence concerns the gene MECP2 and neoplasm.