SLC38A1 and osteosarcoma: Recently, GPNA was also shown to also block the glutamine transporters, SNAT1 and SNAT2.31 Furthermore, CRISPR knockout of ASCT2 in the osteosarcoma cell line 143B resulted in a compensatory upregulation of the SNATs, which may explain the smaller effects seen with stable ASCT2 knockdown compared to GPNA or BenSer inhibition.31 Consistent with a role for other glutamine transporters in endometrial carcinoma we found that SNAT1 is upregulated in endometrial carcinoma compared to normal aged matched endometrium (Supplementary Figure 1A).