Recently, GPNA was also shown to also block the glutamine transporters, SNAT1 and SNAT2.31 Furthermore, CRISPR knockout of ASCT2 in the osteosarcoma cell line 143B resulted in a compensatory upregulation of the SNATs, which may explain the smaller effects seen with stable ASCT2 knockdown compared to GPNA or BenSer inhibition.31 Consistent with a role for other glutamine transporters in endometrial carcinoma we found that SNAT1 is upregulated in endometrial carcinoma compared to normal aged matched endometrium (Supplementary Figure 1A). This evidence concerns the gene SLC1A5 and osteosarcoma.