AZA, DEC and SGI-110 have been shown to induce the expression of multiple, previously suppressed CTAs (such as MAGE-A, NY-ESO-1 and SSX-2) per hypo-methylation of their promoter regions in AML cell lines and in AML xenograft models, as well as in primary AML blasts (Figure 1) [52,55,56,57,58]. This evidence concerns the gene SSX2 and acute myeloid leukemia.