Up-regulation of Snca, Atp5d, Eno4, Ldhb, Pebp1, and Pdhb, and down-regulation of Aco2, Adam17, Eno2, Gapdh, Myh6, Gap43 Pkm2, and Arhgdia were recorded in CRS–NCS as compared to CRS–TLE rats. The gene discussed is ACO2; the disease is congenital rubella syndrome.