Cytotrophoblasts, which do not express Raf kinase inhibitor protein (RKIP), could be one of the reasons for impaired migration of cytotrophoblasts in preeclampsia, because locostatin (the inhibitor of RKIP) induces PAI-1 expression with the support of activation of NF-κB pathway and finally contributes to an inadequate trophoblast invasion [76]. The gene discussed is SERPINE1; the disease is preeclampsia.