Amongst those, 85 were upregulated, and 60 were downregulated in the PFC tissues of both TNBC and PR+BC PDX mice as compared to intact animals (the adjusted p-value was <0.05; the fold change was 1.5) (Fig. 1A) Commonly upregulated genes included bone morphogenetic protein (BMP) and collagen genes, laminins, and histocompatibility loci (Fig. 1B). Here, LAMB2 is linked to breast cancer.