TCF4 and hepatitis C virus infection: The tree shrew (Tupaia belangeri chinensis), a small animalwidely distributed in Southeast Asia and southwest China, has the potential tobe developed as an animal model for hepatitis C. To determine the susceptibilityof the tree shrew to hepatitis C virus (HCV) infection in vitroand in vivo, a well-established HCV, produced from theJ6/JFH1-Huh7.5.1 culture system, was used to infect cultured primary tupaiahepatocytes (PTHs) and tree shrews.