The anti-PDL-1 durvalumab demonstrated clinical activity in several solid tumours, including 19 HCC patients, in a phase 1 study published in 2014 [92]; a randomized open-label phase II study is currently ongoing with durvalumab, tremelimumab, or the combination of the two compounds in patients with unresectable HCC. Here, CD274 is linked to hepatocellular carcinoma.