Moreover, the disease phenotype in this family showed interesting aspects of FEVR pathology: (1) an asymmetrical impairment of the retina, (2) the importance of a follow-up in patients by fluorescein angiography, even in case of a normal (left eye) posterior pole, (3) the necessity of a different treatment approach for the lesions depending on the stages of the disease, and (4) the evidence that inactive lesions may later on constitute an ophthalmological emergency (retinal detachment in the right eye). Here, FZD4 is linked to retinal detachment.