The -129T allele variant in GCLC gene may cause susceptibility to MI [11], renal disease in patients with type 1 diabetes mellitus [23], schizophrenia [20], cystic fibrosis [24], chronic obstructive pulmonary disease [19], and nonalcoholic steatohepatitis in Brazilian patients [21]. This evidence concerns the gene GCLC and chronic obstructive pulmonary disease.