RORA and obesity due to melanocortin 4 receptor deficiency: To explore molecular mechanism by which hepatic deletion of RORα induces obesity and insulin resistance, we performed mRNA-sequencing analysis of liver tissues obtained from HFD-fed RORαf/f, HFD-fed RORαLKO, CD-fed RORαf/f and CD-fed RORαLKO mice (Supplementary Data Table 1).