However, a well-known and well-accepted notion is that type I IFN response of host after viral infection is initiated through recognition of viral products by host pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG-I)-like receptors’, and then such recognition events trigger distinct signaling pathways and ultimately turn on the transcription of type I IFNs [46]. This evidence concerns the gene RIGI and viral infectious disease.