ABCB1 and chronic myelogenous leukemia, BCR-ABL1 positive: Furthermore, ABCB1 is highly overexpressed in doxorubicin-resistant cell lines [90], and β-catenin depletion in a chronic myeloid leukemia cell line leads to reduced ABCB1 mRNA expression, whereas Wnt signaling increases ABCB1 mRNA expression [92].