The KLF5 gene is upregulated in various cancer types, including hepatocellular carcinoma and breast and intestinal cancers, and KLF5 deletion in the presence of induced mutant β-catenin suppresses the transcription of histone deacetylase 1 (HDAC1), which promotes colorectal cancer by promoting both stem and transit-amplifying cell proliferation [57]. Here, KLF5 is linked to colorectal cancer.