In another study, dense intra-tumoral microvessels have been observed near CD133+ glioma CSCs that co-express the CXCR4 [119], and one study has shown that CXCR4+ subpopulations of CD133+ pancreatic CSCs can evade primary tumors and disseminate into the blood stream [120]. The gene discussed is PROM1; the disease is central nervous system cancer.