In a previous study, inhibition of hyaluronan (HA) synthase-2 (HAS2), a biosynthetic enzyme of hyaluoran which is known as one of MMP7 regulators, was shown to decrease MMP7 expression under the condition of HAS2 inhibition and consequently inhibit the invasion ability of colon cancer cells [113]. Here, HAS2 is linked to malignant colon neoplasm.