HNF4A and cancer: Similarly, the specific antibody OMP-18R5 blocks the binding of Wnt ligands to FZD [11] and the small molecule inhibitor CWP23228 prevents the formation of β-catenin/T-cell factor (TCF)/LEF complexes, leading to significant suppression of cancer growth, metastasis, and chemo-resistance through CSC inhibition in breast [12] and liver cancers [8].