Genetic mutations that activate Wnt signaling reportedly contribute to cancer initiation [2], and nuclear accumulation of the Wnt signaling molecules β-catenin and lymphoid enhancer-binding factor 1 (LEF1) have been shown to be positively correlated with poor clinical outcomes, such as cancer progression, invasion, metastasis, and recurrence, resulting in low survival rates [2,3,4]. This evidence concerns the gene LEF1 and cancer.