Among those younger than 65 years, the risk of heart failure was slightly lower in the SGLT2 cohort compared with the DPP4 cohort; however, the association was not significant (aHR 0.77; 95% CI 0.57–1.05; p < .09; Additional file 3: Table S2, Additional file 4: Figure S2). The gene discussed is SLC5A2; the disease is heart failure.