In the overall unmatched cohorts, patients in the SGLT2 cohort had a lower rate of heart failure hospitalization than patients in the DPP4 cohort (109 patients, 2.0% SGLT2 vs 1734 patients, 5.4% DPP4) and the unadjusted HR for the SGLT2 cohort was 0.39 (95% CI 0.32–0.48; p < .001) compared with the DPP4 cohort (Table 2). Here, SLC5A2 is linked to heart failure.