TNF and neoplasm: Other recent studies demonstrated that ABO blood type is associated with serum levels of soluble intercellular adhesion molecule-1 (sICAM-1), tumor necrosis factor-alpha (TNF-α), P-selectin, and soluble E-selectin, suggesting that blood group antigens may influence the chronic systemic inflammatory response, which is associated with the processes of angiogenesis, tumor growth, invasion, and migration [34, 35].