The aim of this study was to analyze the role of a targeted toxin consisting of the ribosome‐inactivating plant toxin dianthin and human epidermal growth factor (HisDianthin‐EGF) in combination with an amphipathic glycoside (SO1861) that serves as an endosomal escape enhancer in order to increase the cytotoxicity in EGFR‐overexpressing pancreatic carcinoma cells. Here, EGF is linked to exocrine pancreatic carcinoma.