Frequencies of the PIK3CA E545K, PIK3CA H1047R, KRAS G12D, and KRAS G12V mutations in carcinomas of the breast, large intestine, lung, and thyroid were collected from the expertly curated data in the COSMIC database (v76) [COSMIC, 2016] (see Supporting Information Table S1). Here, PIK3CA is linked to carcinoma.