We determined that the log10 geomean MFs from the 16 sets of ACB‐PCR MF measurements collected from normal tissues (PIK3CA E545K, PIK3CA H1047R, KRAS G12D, and KRAS G12V in breast, colonic mucosa, lung, and thyroid) were not correlated with the frequencies with which these mutations are reported in carcinomas from each organ (Spearman r = 0.3676, P = 0.1612). The gene discussed is PIK3CA; the disease is carcinoma.