CNTNAP2 and Anxiety: There were no significant differences in tests of locomotor activity (Fig. 5a), motor coordination (accelerating rotarod; Fig. 5b) or in anxiety tests (elevated plus-maze and light–dark box; Fig. 5c/d), although a trend towards less time spent in the light was noted in the CASPR2- IgG exposed mice (P = 0.07; Fig. 5c/d).