Others [5] have also reported CASPR2-antibodies in a high percentage (37%) of selected sera (brain-reactive) in a subgroup of mothers of autistic children compared with 8–12% in the control groups, and have explored the consequences of in utero exposure to a monoclonal CASPR2-reactive antibody derived from one mother of a child with autism in a mouse model. This evidence concerns the gene CNTNAP2 and autism.