Several genes previously recognized as tumor suppressors and oncogenes in other cancers including e.g. RASSF1, miR-663, ARID5B, FIP1L1, BCL6, TRPM2, ADORA1, ADORA2A, TFA2PA, and DIRC2 were among the “ASXL1 methylation signature genes”. The gene discussed is ARID5B; the disease is cancer.