CASP8 and cancer: Ingenuity pathway analysis revealed that differentially methylated CpG sites were annotated to genes involved in ‘cancer’ (e.g. WT1, BIN1, PCDHA6, RIPK4, SOCS3, KTN1), ‘cellular growth and proliferation’ (e.g. mir-146, WT1, FOXP1, CEBPE, IGF2BP1, IGF1R, CASP8), ‘immunological diseases’ (e.g. BCL2L1 and MICA) and in ‘cell death and survival’ (e.g. SOCS3, mir-146, UHRF1, and CASP8) (Figure S2C).