RETREG1 and neoplasm: Its genetic mutation, resulting in decreased FAM134B expression, is a frequent event in the progression of oesophageal squamous cells47 and colorectal cancers48, which is adversely associated with patient clinical and pathological parameters and congruent with the tumor suppressive properties of FAM134B as previously reported48 as well as demonstrated in this study (Figs 6 and 7).