The association between CDC25B expression and cell proliferation is multifaceted: on one hand, CDC25B is up-regulated in multiple tumor types with increased levels correlated with higher proliferation, and its elevated level in the mammary glands has led to accelerated mammary epithelial proliferation that ultimately leads to tumor formation when exposed to the carcinogen DMBA in vivo81; on the other hand, its tumor suppressive roles and anti-proliferative effect have been reported by several studies81, 82. Here, CDC25B is linked to neoplasm.