Genes enriched in these 5 pathways are ER, HER3, MCM2, MCM5, CDT1, CCND3, CDKN2A, RANGAP1, AURKA, HSPB1, GAPDH. Genes such as ER and HER3 reflect the proliferative property of breast cancer cells. This evidence concerns the gene CDKN2A and breast cancer.