Lastly, in contrast to tissue array and the immunoassay used by Colon-Caraballo et al. 23, the use of multiple assays, careful choice of cellular component to observe and both in vivo and in vitro experiments in our study provide pieces of coherent, consistent and biologically plausible evidence that EZH2 and its catalytic product H3K27me3 are aberrantly expressed in endometriosis. The gene discussed is EZH2; the disease is endometriosis.