Pathway enrichment analysis also revealed that downregulated genes were mainly enriched in several pathways belonged to the innate immune system such as: “Fc gamma R-mediated phagocytosis”, “Chemokine signaling pathways”, “Toll like receptors signaling pathway” and “MTOR signaling pathway”, reflects the deficiencies of innate immune function in primary monocytes of the XLA patients. This evidence concerns the gene MTOR and Bruton-type agammaglobulinemia.