Decreased expression of 32 core genes involved in “chemokines signaling pathway” including 4 chemokine receptors (CXCL16, CXCR1, CXCR2, CXCR4) were also observed in primary monocytes of the XLA patients (Table 3). The gene discussed is CXCR2; the disease is Bruton-type agammaglobulinemia.