The comparison of paired HNSCC tissue samples and patient-matched normal mucosa pointed to a fundamental regulatory control of ANXA1 by miR-196a/b in HNSCC, while in vitro studies established specificity for ANXA1, leaving ANXA2 unchanged, and the reproducibility in different cell types (Fig. 4). Here, ANXA2 is linked to head and neck squamous cell carcinoma.