The study of ANXA1 promoter constructs in HNSCC-derived cell lines also established the presence of active regulatory sites in the 5′ non-transcribed region (−172 to −38 bp) (Fig. 6) with potential binding sites for transcription factors such as FOX, NFAT, p53, AP1, Sp1, CCAT, CEBP, TAT, GATA, corroborating and extending previous studies29, 30. The gene discussed is TAT; the disease is head and neck squamous cell carcinoma.