It is particularly noteworthy that ANXA1 and miR-196a have been shown to coregulate each other in a negative feedback loop in breast cancer through c-myc and NFkappaB11 and that ANXA1 regulation of other microRNAs and transcription factors could further contribute to the accompanying changes in NFkappaB and miR-19610. This evidence concerns the gene ANXA1 and breast carcinoma.