Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the nuclear effectors of the Hippo pathway, regulate organ growth and are potent drivers of tumor formation (Harvey et al., 2013; Johnson and Halder, 2014; Piccolo et al., 2014; Yu et al., 2015). This evidence concerns the gene YAP1 and neoplasm.