The GWAS SNP rs11212617, which is associated with the effectiveness of metformin in treating type 2 diabetes [42], lies within a large haplotype block of 340 kb that encompasses genetic variants like rs227091 (Fig. 4c, d) that can affect RNA editing of the ATM gene based on our edQTL and ASED analysis. The gene discussed is ATM; the disease is type 2 diabetes mellitus.