In this study, we prepared the sample by water decoction method, which is commonly used for TCM clinically, and then established the chromatographic fingerprint of AD and the evaluation model of effect on tyrosinase activity in vitro, analyzed the relationship between the characteristic peaks with the pharmacodynamic value with the established mathematical model, fitted the active components related to inhibition on tyrosinase, so as to provide reference for the pharmacodynamic material basis of AD. This evidence concerns the gene TYR and Alzheimer disease.