IAPP and pancreatic insulinoma: Epigallocatechin gallate (EGCG), an important polyphenol found in green tea, has been shown to redirect amyloid fibril formation from fibrillogenic forms to non fibrillogenic oligomers; i.e., “off-pathway” aggregates that are unable to form amyloid [155,156] and have been shown to protect rat insulinoma, INS-1, cells from IAPP amyloid-induced cytotoxic effects [157].