CLEC7A and arthritic joint disease: Dectin-1 signaling on dendritic cells potently induce the production of IL-23 that promotes Th17 differentiation [47], and the dectin-1 agonist β-glucan triggers the development of not only arthritis, but also psoriatic skin lesions, uveitis, or enthesitis, which are similar to human spondyloarthropathies [48].