IL-1 and TNF-α were required for arthritis induced by the transfer of anti-type II collagen antibodies (CAIA), while IL-6 was imperative for arthritis induced by the immunization with type II collagen (CIA), because IL-6 was essential for the differentiation of Th17 cells [22,23,24] (Table 1). This evidence concerns the gene TNF and arthritic joint disease.