HTT and Huntington disease: Other studies suggest that some antioxidant polysaccharides exert their neuroprotective effects by targeting polyQ aggregate itself, e.g., L. barbarum polysaccharide not only increases the viability of HEK293 cells that express mutant-huntingtin containing 160 glutamine repeats but also improves motor behavior and lifespan in HD-related transgenic mice [122].