CSF2 and neoplasm: At the same time, a number of inflammatory factors in the tumor microenvironment such as IL-2, IL-6, IL-8, IL10, macrophage inflammatory protein 1 α (MIp1α), IFN-β, Transforming growth factor β (TGF-β), regulated on activation, normal T cell expressed and secreted (RANTES), and granulocyte-macrophage colony-stimulating factor (GMCSF) participate in regulation of autophagy in tumor cells [41,42].