Many studies have been reported that API has anti-arthritic properties: Suppression of the collagenase activity involved in RA [26]; protection against CIA [12]; induction of apoptosis in rheumatoid fibroblast-like synoviocytes by reactive oxygen species (ROS) and activation of ERK1/2 [27]. The gene discussed is MAPK3; the disease is rheumatoid arthritis.