TNF and rheumatoid arthritis: However, the use of standard drugs in RA is known to produce a variety of side effects: Infusion hypersensitivity reactions with the use of TNF-α inhibitors [5]; gastrointestinal ulcerations and hemorrhagic events triggered by NSAID [6]; higher risk of infection due to the use of biological drugs [7]; etc. Therefore, the need for new cure in RA is still high.