INS and obesity due to melanocortin 4 receptor deficiency: In rodents, EGCG and green tea extract have been shown in most studies to reduce total body and adipose tissue weights [37,48,49], decrease blood/plasma glucose and insulin levels [37,48,50], improve insulin sensitivity [37,48], blood pressure, and lipid profile [37,48,51], and reduce unfavorable obesity-associated changes in gut microbiota [52].