For example, DUOXA/NIP affects differentiation in murine skeletal muscle myoblasts [125], murine thyroid hormone production and cerebellar development [126], and the response to bacterial infections in the murine gut [127], as well as development of the exoskeleton in C. elegans [128], and recruitment of hemocytes to wounds in the Drosophila embryo epidermis and neutrophils to airways in mice [129,130]. This evidence concerns the gene DUOXA1 and bacterial infectious disease.