RhoJ deletion significantly inhibited the growth of melanoma tumors that expressed either no PTEN (p<0.0001, Log-rank; Fig 1A) or had one functional copy of PTEN (p<0.0001, Log-rank; Fig 1B), suggesting that RhoJ drives tumor growth by amplifying BRAF and not AKT signaling. This evidence concerns the gene RHOJ and neoplasm.