HMGA2 and neoplasm: The expression of the IMP2 gene is strongly upregulated by the oncofetal HMGA2 oncogene (Brants et al., 2004; Cleynen et al., 2007; Li et al., 2012) and the mRNA encoding the oncogenic transcriptional modifier HMGA1 (Fedele and Fusco, 2010; Ozturk et al., 2014, Sumter et al., 2016), previously detected as an IMP2 client (Janiszewska et al., 2012), is identified here as an important mediator of IMP2’s tumor promoting activity.