IMP3 and cancer: Moreover, the absolute abundance of IMP2 mRNA in all but a few cancers far exceeds that of the IMP1 and IMP3 paralogues (Figure 1B), even in those cancers wherein the fold amplification of IMP1/IMP3 RNA over their level in the normal tissue is much greater than that of IMP2. Thus, IMP2 is nearly always the most abundant IMP paralogue in human cancers and its overexpression occurs at a high frequency.