HMGA1 and neoplasm: Regarding mechanism by which IMP2 protects HMGA1 mRNA, Degrauwe et al. (2016b) demonstrated in Glioblastoma stem cells that IMP2 binding to the HMGA1 mRNA 3’UTR (Figure 5—figure supplement 1) overlaps the binding site of the pro-differentiation tumor suppressor miR, Let-7 and antagonizes Let-7’s ability to promote HMGA1 mRNA degradation.