IGF2 and rhabdomyosarcoma: In RD rhabdomyosarcoma cells, the concurrent dual phosphorylation of IMP2 Ser162 and Ser164 is inhibited by rapamycin coincident with inhibition of IMP2 binding to the IGF2 leader 3 5’UTR (Dai et al., 2011) and IGF2 leader 3 mRNA translation by internal ribosomal entry.