Herein we demonstrate that although the oncofetal IMPs are commonly reexpressed in human cancers, IMP2 is usually much more abundant in most human cancers than its paralogs IMP1or IMP3 (Bell et al., 2013, Lederer et al., 2014); moreover, the IMP2 gene is amplified at a high frequency in several common solid tumors, a phenomenon rarely seen with the IMP1 or IMP3 genes. The gene discussed is IGF2BP1; the disease is cancer.