IGF2 and rhabdomyosarcoma: We showed previously that transfection of Flag-IMP2(Ser162Asp/Ser164Asp) stimulated the translation of an IGF2-leader 3-luciferase reporter in RD rhabdomyosarcoma cells to an extent similar to Flag-IMP2 wildtype, whereas Flag-IMP2(Ser162Ala/Ser164Ala) was no more effective than empty vector (Dai et al., 2011); this translational response was paralleled by the ability of the IMP2 variants to bind the IMP2 leader 3 5’UTR RNA.