The expression of the IMP2 gene is strongly upregulated by the oncofetal HMGA2 oncogene (Brants et al., 2004; Cleynen et al., 2007; Li et al., 2012) and the mRNA encoding the oncogenic transcriptional modifier HMGA1 (Fedele and Fusco, 2010; Ozturk et al., 2014, Sumter et al., 2016), previously detected as an IMP2 client (Janiszewska et al., 2012), is identified here as an important mediator of IMP2’s tumor promoting activity. Here, HMGA1 is linked to neoplasm.