HMGA1 and cancer: The dependence of HMGA1 abundance on IMP2 demonstrated for MEFs (Figure 5I) is observed in all of the other cancer derived cell lines examined; elimination of IMP2 is accompanied by a major reduction in HMGA1 polypeptide (Figure 4A) whereas forced overexpression of IMP2 in HCC1419 and H2029 cells causes a dose-dependent increase in HMGA1 (Figure 4B).