MGMT and central nervous system cancer: In this context, it should be noted that RT by itself is known to increase the BBB permeability and theoretically enhance the delivery of AMONs to the tumor site, from where radiation-enhanced upregulation of physiological endocytosis will facilitate its intracellular delivery.67 MGMT-expressing glioma cell lines are less invasive and are known to be difficult to grow in animal models.68 Further, the optimal combination or ratio of sequences was not determined.