The authors analyzed the tissular concentration of these enzymes observing that in the spinal cord, the enzymes involved in FA β-oxidation like ACAA1 and ACAA2, as well as those related to early steps of FA desaturation, like FADS2, were all increased in the analyzed ALS samples (ranging between 20 to 110%) [135]. Here, ACAA1 is linked to amyotrophic lateral sclerosis.