FASN and cancer: Analogously, some downstream cancer cell lipid metabolism transcription factors and signal regulating genes are overexpressed; in particular, FASN is controlled by growth factor receptor-associated signalling pathways, including the PI3K-Akt (phosphatidylinositol 3-kinase) and MAPK (mitogen-activated protein kinase), through the SREBP-1 transcription factor [77, 83].