Platelet membranes contain integrins (e.g., glycoproteins Ib-IX-V (GP Ib-IX-V), glycoprotein VI (GP VI), and glycoprotein IIb-IIIa (GP IIb-IIIa), integrin αIIbβ3), thromboxane (TxA2) receptor (TPR), purigenic P2 receptors for nucleotides (adenosine diphosphate (ADT) and adenosine triphosphate (ATP)) as well as protease-activated receptors for thrombin (PAR-1 and PAR-4) that are intimately involved in cancer progression [13]. The gene discussed is F2R; the disease is cancer.