Biomarkers of platelet activation in cancer patients are soluble P-selectin, thrombospondin 1, TSP-1, β-thromboglobulin, CD40 ligand, transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), angiopoetin-1 (AP-1), matrix proteins, CCL17, CCXL1, CXCL5, and others [2, 48, 49]. The gene discussed is THBS1; the disease is cancer.